Pump Spray | Arginine Ursolic Acetate | Triacetyladenosine | Neovascularization
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Pump Spray - Neovascularization
Neovascularization (also known as angiogenesis) is the formation of new vascular pathways. In the case of skeletal muscle, neovascularization is a healthy response that is stimulated by exercise. Intense exercise stimulates reactions in the muscle which increase its size, strength, as well as endurance. To support this larger and stronger muscle tissue there must be a corresponding increase in the ability of your body to feed the new tissue. This is where neovascularization comes into play.
Many people hit plateaus in training. Their muscles grow only so big and then they find it hard to make any further gains. This can be due to limitations in many areas, including the ability to activate genes that promote protein synthesis and/or an inability to repress genes responsible for protein degradation. It may also of course be due to inadequate intake of proper protein, calories, and essential nutrients to support muscle growth. Another possibility is that the body is unable to supply the muscle with the proper oxygen and substrates needed to support growth because the network of blood vessels and capillaries feeding it have not been adequately developed.
Much like how an army can only advance so far without adequate supply lines, your muscles can only grow so large without adequate vascular infiltration. This is where Pump Spray comes to the rescue. Pump Spray’s two ingredients are proven to increase the production of vascular endothelial growth factor -1 (VEGF1), which is the signal protein released by muscle when it undergoes stress due to exercise that depletes oxygen and energy substrates. VEGF1 signals the muscles to sprout new blood vessels and capillaries off of existing ones to facilitate the growth and metabolic adaptations needed to handle the exercise strain.
By supporting and enhancing your body’s own natural neovascularization response, you ensure that you maintain optimal anabolic supply lines so that your muscles can continue their hypertrophic blitzkrieg offensive! Not to mention the fact that roadmap veins covering your muscles definitely make a formidable fitness statement!
For further technical reading regarding the ingredients in Pump Spray and their roles in neovascularization of muscle tissue check out the following references.
Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H857-62. Epub 2010 Jun 11.
Contraction-inducesecretion of VEGF from skeletal muscle cells is mediated by adenosine.
Høier B, Olsen K, Nyberg M, Bangsbo J, Hellsten Y.
Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R283-R296.
Growth regulation of the vascular system: an emerging role for adenosine.
High Alt Med Biol. 2008 Summer;9(2):158-66.
Skeletal muscle capillarity during hypoxia: VEGF and its activation.
Breen E, Tang K, Olfert M, Knapp A, Wagner P.
J Appl Physiol. 1999 May;86(5):1513-8.
Effect of NO, vasodilator prostaglandins, and adenosine on skeletal muscle angiogenic growth factor gene expression.
Benoit H, Jordan M, Wagner H, Wagner PD.
Adv Exp Med Biol. 2001;502:349-63.
Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia.
Biochem Biophys Res Commun. 2008 Jul 4;371(3):556-60. Epub 2008 Apr 28.
Modulation of angiogenic factors by ursolic acid.
Kiran MS, Viji RI, Sameer Kumar VB, Sudhakaran PR.
J Agric Food Chem. 2010 Dec 22;58(24):12941-9. Epub 2010 Nov 12.
Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increasesneovascularization.
Lee AW, Chen TL, Shih CM, Huang CY, Tsao NW, Chang NC, Chen YH, Fong TH, Lin FY.
Can J Cardiol. 1986 Mar-Apr;2(2):120-3.
Angiogenesis in the heart and skeletal muscle.
Hudlicka O, Wright AJ, Ziada AM